Ogasawara K, Hata Y, Une Y, Sasaki F, Nakajima Y, Uchino J, Ito Y, Kawai T
First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
Nihon Geka Gakkai Zasshi. 1994 Aug;95(8):521-7.
We clinically analyzed significance of serum human hepatocyte growth factor (hHGF) concentrations (ng/ml) before and after hepatectomies. We examined 39 hepatectomized patients (Group H) and 8 non-hepatectomized patients as control (Group C). In group H, hHGF levels elevated significantly on postoperative 1st, 3rd, 5th, and 7th days (0.59 +/- 0.24, 0.47 +/- 0.23, 0.38 +/- 0.16, 0.38-0.14, respectively) compared with the preoperative value (0.27 +/- 0.11). On the 3rd day hHGF levels in Group H (0.45 +/- 0.22) were significantly higher than those in Group C (0.30 +/- 0.06). Nineteen cases of 2-segmentectomy and 8 cases of partial resection showed significantly higher hHGF levels on the 3rd day than those in Group C. In 12 patients with liver cirrhosis, hHGF levels were significantly higher on the 5th and 21st days than those in 27 patients without cirrhosis. Three patients with hepatic failure showed significantly higher hHGF levels correlated conversely with preoperative serum albumin and hHGF levels on the 1st day after operation significantly correlated with operative time, blood loss during the operation. It was suggested that serum hHGF level correlated with hepatic functional reserve. We concluded that serial measurement of hHGF was useful for evaluation of postoperative damage of hepatic functions, and prolonged high hHGF levels might suggest hepatic failure.
我们对肝切除术前、后血清人肝细胞生长因子（hHGF）浓度（ng/ml）的临床意义进行了分析。我们检查了39例接受肝切除的患者（H组）和8例未接受肝切除的患者作为对照（C组）。在H组中，术后第1、3、5和7天hHGF水平显著升高（分别为0.59±0.24、0.47±0.23、0.38±0.16、0.38 - 0.14），与术前值（0.27±0.11）相比。在第3天，H组的hHGF水平（0.45±0.22）显著高于C组（0.30±0.06）。19例二段切除术和8例部分切除术患者在第3天的hHGF水平显著高于C组。在12例肝硬化患者中，第5天和第21天的hHGF水平显著高于27例无肝硬化患者。3例肝衰竭患者的hHGF水平显著升高，与术前血清白蛋白呈相反相关，术后第1天的hHGF水平与手术时间、术中失血量显著相关。提示血清hHGF水平与肝功能储备相关。我们得出结论，连续测量hHGF有助于评估术后肝功能损害，hHGF水平持续升高可能提示肝衰竭。
