Kobayashi S, Amikura R, Okada M
Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan.
Science. 1993 Jun 4;260(5113):1521-4. doi: 10.1126/science.7684857.
Mitochondrial large ribosomal RNA (mtlrRNA) has been identified as a cytoplasmic factor that induces pole cell formation in embryos whose ability to form a germ line has been abolished by treatment with ultraviolet light. In situ hybridization analyses reveal that mtlrRNA is enriched in germ plasm and is tightly associated with polar granules, the distinctive organelles of germ plasm, which supports the idea that mtlrRNA functions in pole cell formation. This suggests that a product from the mitochondrial genome, along with nuclear products, participates in a key event in embryonic development: determination of the germ line.
线粒体大核糖体RNA（mtlrRNA）已被鉴定为一种细胞质因子，它能在经紫外线处理后生殖系形成能力已被消除的胚胎中诱导极细胞形成。原位杂交分析表明，mtlrRNA在生殖质中富集，并与极颗粒紧密相关，极颗粒是生殖质的独特细胞器，这支持了mtlrRNA在极细胞形成中发挥作用的观点。这表明线粒体基因组的一种产物与核产物一起参与了胚胎发育中的一个关键事件：生殖系的决定。
