重组人粒细胞集落刺激因子治疗与常见变异型免疫缺陷相关的周期性中性粒细胞减少症。
Recombinant human granulocyte colony-stimulating factor therapy for cyclic neutropenia associated with common variable immunodeficiency.
作者信息
Tsuda M, Urakami T, Watanabe S, Shimizu H, Inana I, Kikkawa Y, Kitagawa T
机构信息
Department of Pediatrics, Nihon University, School of Medicine, Tokyo, Japan.
出版信息
Acta Paediatr Jpn. 1993 Apr;35(2):124-6. doi: 10.1111/j.1442-200x.1993.tb03021.x.
A 14 year old boy with common variable immunodeficiency (CVID) had regularly recurring episodes of severe infections independently of the serum gamma-globulin level. Serial blood counts revealed that this patient also had cyclic neutropenia. Recently, recombinant human granulocyte colony-stimulating factor (rhG-CSF) was reported to be an effective treatment for this disease. We tried rhG-CSF therapy for this patient and a prompt increase in the neutrophil count was noted. However, the cyclic alterations and duration of the nadir of the neutrophil count were not altered, which suggested that rhG-CSF has a variable efficacy in at least some patients with cyclic neutropenia.
一名患有常见变异型免疫缺陷（CVID）的14岁男孩，无论血清γ-球蛋白水平如何，都会定期出现严重感染发作。连续血常规检查显示该患者还患有周期性中性粒细胞减少症。最近，据报道重组人粒细胞集落刺激因子（rhG-CSF）是治疗这种疾病的有效方法。我们对该患者尝试了rhG-CSF治疗，发现中性粒细胞计数迅速增加。然而，中性粒细胞计数的周期性变化和最低点持续时间并未改变，这表明rhG-CSF对至少一些周期性中性粒细胞减少症患者的疗效存在差异。
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