Yu Y L, Yang G Z
Department of Immunology, School of Basic Medicine, Bethune University of Medical Sciences, Changchun.
Chin Med J (Engl). 1993 Jan;106(1):13-6.
Tumor necrosis factor alpha (TNF alpha) mRNA expression in bronchoalveolar lavage (BAL) cells from patients with lung fibrosis was studied by a reverse transcription-DNA polymerase chain reaction (RT-PCR). The results indicated that two thirds of the tested samples were TNF alpha mRNA positive. On the other hand, TNF alpha activity was detected in a big part of the BAL supernatants from the patients. Furthermore, recombinant TNF alpha was found to be mitogenic to lung fibroblasts. These data suggest that TNF alpha expression in BAL cells may play a role in the development of lung fibrosis in human.
采用逆转录 - DNA聚合酶链反应（RT-PCR）研究了肺纤维化患者支气管肺泡灌洗（BAL）细胞中肿瘤坏死因子α（TNFα）mRNA的表达。结果表明，三分之二的检测样本TNFα mRNA呈阳性。另一方面，在这些患者的大部分BAL上清液中检测到TNFα活性。此外，发现重组TNFα对肺成纤维细胞有促有丝分裂作用。这些数据表明，BAL细胞中TNFα的表达可能在人类肺纤维化的发展中起作用。
