Murphy T L, Cooper I A, Wray G W, Ironside P N, Matthews J
J Natl Cancer Inst. 1976 Feb;56(2):215-9. doi: 10.1093/jnci/56.2.215.
tRNA levels, base composition, and tRNA methylase activities of normal and tumor tissue from the spleens of 24 patients (18 with Hodgkin's disease and 6 with histiocytic lymphoma) were studied. There were no significant differences in major base composition of normal and tumor tissue. Methylated guanosine was increased in tumor tissue of some patients, and tRNA methylase activities were increased in extracts from the tumors.
对24例患者（18例霍奇金病患者和6例组织细胞淋巴瘤患者）脾脏的正常组织和肿瘤组织的tRNA水平、碱基组成及tRNA甲基化酶活性进行了研究。正常组织和肿瘤组织的主要碱基组成无显著差异。部分患者肿瘤组织中的甲基化鸟苷增加，肿瘤提取物中的tRNA甲基化酶活性升高。
