Metcalfe S, Ashley N, Chen Z, Calne R Y
Department of Surgery, University of Cambridge, UK.
Int Arch Allergy Immunol. 1993;101(2):132-5. doi: 10.1159/000236510.
Prodigiosin 25C inhibited both lymphocyte activation (concanavalin-A-activated mouse spleen cells) and constitutive cell cycling of T cells and fibroblasts. This suggests that prodigiosin 25C is not selective for activation of T lymphocytes as has been previously reported. Use of prodigiosin 25C to suppress allograft rejection of rat hearts (DA to PVG) showed that 1 mg/kg/day i.p. had no effect whilst 10 mg/kg/day i.p. was toxic as manifest by weight loss and diarrhoea at 3 days. Although this toxicity was reversible upon reversion to 1 mg/kg/day, no major prolongation in allograft survival was seen. Our data suggests that prodigiosin 25C has a low therapeutic index and may not be selective for T cell activation.
灵菌红素25C抑制淋巴细胞激活（刀豆球蛋白A激活的小鼠脾细胞）以及T细胞和成纤维细胞的组成性细胞周期进程。这表明，灵菌红素25C并不像先前报道的那样对T淋巴细胞激活具有选择性。使用灵菌红素25C抑制大鼠心脏（从DA到PVG）同种异体移植排斥反应的实验表明，腹腔注射1毫克/千克/天没有效果，而腹腔注射10毫克/千克/天则具有毒性，表现为3天时体重减轻和腹泻。尽管这种毒性在恢复到1毫克/千克/天时是可逆的，但同种异体移植物存活时间并未显著延长。我们的数据表明，灵菌红素25C的治疗指数较低，可能对T细胞激活没有选择性。
