Nakamura A, Nagai K, Ando K, Tamura G
J Antibiot (Tokyo). 1986 Aug;39(8):1155-9. doi: 10.7164/antibiotics.39.1155.
In the course of screening for immunomodulating substances among microbial metabolites using a triple mitogen assay system, we detected an immunosuppressive activity which is similar to cyclosporin A. Two active components were isolated as red pigments from the fermentation broth of Streptomyces hiroshimensis and they were identified with prodigiosin 25-C and metacycloprodigiosin respectively. These compounds inhibited T lymphocyte proliferation which was induced by plant lectins, concanavalin A (Con A) and phytohemagglutinin (PHA), much more extensively than B lymphocyte proliferation which was induced by lipopolysaccharide (LPS). Prodigiosin 25-C completely inhibited induction of cytotoxic T cells in a mixed lymphocyte reaction (MLR) at 4 ng/ml.
在使用三联丝裂原检测系统筛选微生物代谢产物中的免疫调节物质的过程中，我们检测到一种与环孢菌素A相似的免疫抑制活性。从广岛链霉菌发酵液中分离出两种活性成分作为红色素，它们分别被鉴定为灵菌红素25-C和间型灵菌红素。这些化合物对植物凝集素伴刀豆球蛋白A（Con A）和植物血凝素（PHA）诱导的T淋巴细胞增殖的抑制作用，比脂多糖（LPS）诱导的B淋巴细胞增殖的抑制作用更为广泛。灵菌红素25-C在4 ng/ml时完全抑制混合淋巴细胞反应（MLR）中细胞毒性T细胞的诱导。
