Pascual J M, Runyon D E, Watson J C, Clifford C B, Dubick M A, Kramer G C
Division of Military Trauma Research, Letterman Army Institute of Research, San Francisco, California.
Circ Shock. 1993 Jun;40(2):115-24.
A 7.5% sodium chloride/6% Dextran solution (HSD) is effective for restoration of cardiovascular function after hemorrhagic shock. In the present experiments, we tested the usefulness and side effects of a 25% NaCl/24% Dextran solution (SSD), compared to HSD and 0.9% NaCl (NS). After 1 hr of baseline observation, 21 anesthetized pigs were submitted to hemorrhagic shock, maintaining a mean arterial pressure of 45 mmHg for 60 min. Continuous intravenous infusion of one of the solutions was then initiated and the infusion rate adjusted to restore and maintain cardiac output at baseline levels for 2 hr. The NS group required 121 +/- 22 ml/kg to achieve full resuscitation, while the HSD and SSD groups required 6.3 +/- 1.3 and 1.7 +/- 0.2 ml/kg, respectively. We conclude that SSD infusions were exceedingly effective at restoring cardiovascular function in volumes equal to only 10% of bled volume, but were associated with transient hemolysis and peripheral vein inflammation.
7.5%氯化钠/6%右旋糖酐溶液（高渗盐右旋糖酐溶液，HSD）对失血性休克后心血管功能的恢复有效。在本实验中，我们测试了25%氯化钠/24%右旋糖酐溶液（超渗盐右旋糖酐溶液，SSD）相较于HSD和0.9%氯化钠溶液（生理盐水，NS）的有效性及副作用。在1小时的基线观察后，21头麻醉猪遭受失血性休克，将平均动脉压维持在45 mmHg达60分钟。随后开始持续静脉输注其中一种溶液，并调整输注速率以将心输出量恢复并维持在基线水平2小时。生理盐水组需要121±22 ml/kg才能实现完全复苏，而高渗盐右旋糖酐溶液组和超渗盐右旋糖酐溶液组分别需要6.3±1.3和1.7±0.2 ml/kg。我们得出结论，输注超渗盐右旋糖酐溶液在恢复心血管功能方面极为有效，所需容量仅相当于失血容量的10%，但会伴有短暂的溶血和外周静脉炎症。
