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[造血生长因子]

[Hematopoietic growth factors].

作者信息

Stoppa A M, Blaise D, Viens P, Baume D, Mannoni P, Maraninchi D

机构信息

Institut Paoli Calmettes, Marseille.

出版信息

Presse Med. 1993 Mar 20;22(10):487-90.

PMID:7685523
Abstract

Haematopoietic growth factors are a family of genetically determined low molecular weight glycoproteins which regulate the proliferation and differentiation of haemopoietic cells through specific membrane receptors. GCSF and GMCSF reduce the morbidity from infections associated with the neutropenia induced by chemotherapy of onco-haematological neoplasia; EPQ totally corrects not only the anaemia of patients with chronic renal failure, but also 50 percent of anaemias related to chemotherapy; finally, the activity of IL 3 on platelet production seems to control the thrombocytopenia which restricts the use of therapeutics.

摘要

造血生长因子是一类由基因决定的低分子量糖蛋白,它们通过特定的膜受体调节造血细胞的增殖和分化。粒细胞集落刺激因子(GCSF)和粒细胞巨噬细胞集落刺激因子(GMCSF)可降低肿瘤血液学肿瘤化疗诱导的中性粒细胞减少相关感染的发病率;促红细胞生成素(EPO)不仅能完全纠正慢性肾功能衰竭患者的贫血,还能纠正50%与化疗相关的贫血;最后,白细胞介素3(IL 3)对血小板生成的作用似乎能控制限制治疗应用的血小板减少症。

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