进一步分析圆田螺凝集素与原发性乳腺癌结合对腋窝和内乳淋巴结转移的预测价值。
Further analysis of predictive value of Helix pomatia lectin binding to primary breast cancer for axillary and internal mammary lymph node metastases.
作者信息
Noguchi M, Thomas M, Kitagawa H, Kinoshita K, Ohta N, Nagamori M, Miyazaki I
机构信息
Operation Center, Kanazawa University Hospital, School of Medicine, Japan.
出版信息
Br J Cancer. 1993 Jun;67(6):1368-71. doi: 10.1038/bjc.1993.253.
We investigated the relation between Helix pomatia (HPA) staining of primary breast cancer and the presence of axillary (AX) or internal mammary (IM) metastases, and evaluated its predictive value for AX or IM metastases in comparison with the use of clinical variables. There was a significant association between the HPA staining and AX or IM metastases. When HPA staining was regarded as an indicator of AX metastases, a diagnostic accuracy of 72%, a sensitivity of 69% and a specificity of 75% were achieved. As an indicator of IM metastases, these values were 64%, 76% and 62%, respectively. In predicting the presence of AX metastases using a discriminant function with clinical AX status, location of tumour and tumour size, diagnostic accuracy, sensitivity and specificity were 79%, 69% and 87%, respectively. In predicting the presence of IM metastases using the discriminant function with clinical AX status and tumour size, these values were 74%, 71% and 75%, respectively. Therefore, it was concluded that the HPA staining may be useful, but it was equivalent with the discriminant function with clinical variables in prediction of AX or IM metastases.
我们研究了原发性乳腺癌的苹果螺（HPA）染色与腋窝（AX）或内乳（IM）转移之间的关系，并与使用临床变量相比，评估了其对AX或IM转移的预测价值。HPA染色与AX或IM转移之间存在显著关联。当将HPA染色视为AX转移的指标时，诊断准确率为72%，敏感性为69%，特异性为75%。作为IM转移的指标，这些值分别为64%、76%和62%。使用包含临床AX状态、肿瘤位置和肿瘤大小的判别函数预测AX转移的存在时，诊断准确率、敏感性和特异性分别为79%、69%和87%。使用包含临床AX状态和肿瘤大小的判别函数预测IM转移的存在时，这些值分别为74%、71%和75%。因此，得出的结论是，HPA染色可能有用，但在预测AX或IM转移方面，它与包含临床变量的判别函数相当。
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