Weston A
Molecular Epidemiology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Mutat Res. 1993 Jul;288(1):19-29. doi: 10.1016/0027-5107(93)90204-s.
This report has attempted to summarize the principles, advantages, limitations and the source of data derived in the use of physical detection techniques for DNA-adduct measurement in human biomonitoring. Each method, although inherently chemically-specific, has advantages and limitations depending on the adduct type under study. These methods have a niche that is at least consistent with corroborative technology, and are being applied to dosimetry problems in the field.
本报告试图总结在人体生物监测中使用物理检测技术测量DNA加合物的原理、优点、局限性及数据来源。每种方法虽然本质上具有化学特异性，但根据所研究的加合物类型，各有优缺点。这些方法都有其独特的应用领域，至少与确证技术相一致，并且正在被应用于该领域的剂量测定问题。
