Sauer H, Wilmanns W
Klin Wochenschr. 1976 Mar 1;54(5):197-202. doi: 10.1007/BF01469125.
Chemotherapy of malignant tumors can be made more effective by synchronization of the cell cycle. Synchronization therapy consists of a synchronizing step (phase I), an interval and a cytocidal step (phase II). Some regimens till now approved in clinical treatment are presented. The results are found to be encouraging. In all schedules three effects work together namely synchronization recruitment, summation.
通过使细胞周期同步化,恶性肿瘤的化疗可以更有效。同步化疗法包括一个同步化步骤(I期)、一个间隔期和一个杀细胞步骤(II期)。文中介绍了一些目前已获临床治疗批准的方案。结果令人鼓舞。在所有方案中,有三种效应共同起作用,即同步化募集、叠加效应。