Koga H, Mori K, Tokunaga Y
Department of Neurosurgery, Nagasaki University School of Medicine, Japan.
Neurol Med Chir (Tokyo). 1993 May;33(5):290-4. doi: 10.2176/nmc.33.290.
An interstitial radiofrequency (RF) hyperthermia system for brain tumor was evaluated in cranial phantoms and cat brains. An intracranial RF applicator and thermocouple microprobes were emplaced in the brain and a headband-type flexible extracranial electrode fixed over the scalp. An 8 MHz RF capacitive-type heating machine provided power. The temperature distribution was measured by thermography. In phantom and animal studies, the RF power had good penetration into the tissue and generated uniform and easily controllable high-temperature fields within the intracranial cavity. There was little change in temperature near or in the cranium itself. Six cases of human malignant glioma were treated with this interstitial RF hyperthermia system, achieving therapeutic temperature without adverse effects.
一种用于脑肿瘤的间质射频（RF）热疗系统在颅骨模型和猫脑上进行了评估。将颅内射频施加器和热电偶微探针置于脑内，并在头皮上固定一个头带式柔性颅外电极。一台8兆赫兹的射频电容式加热机提供能量。通过热成像测量温度分布。在模型和动物研究中，射频能量对组织有良好的穿透性，并在颅内腔内产生均匀且易于控制的高温场。颅骨附近或颅骨内的温度几乎没有变化。使用这种间质射频热疗系统治疗了6例人类恶性胶质瘤患者，达到了治疗温度且无不良反应。
