De Agostini A, Mascaro L, Pizzocaro C, Panarotto M B, Bestagno M
Medical Physics Department, Spedali Civili di Brescia, Italy.
J Nucl Biol Med (1991). 1993 Mar;37(1):38-44.
Measurement of radioactivity levels in the urine of patients undergoing strontium-89 therapy can be used to evaluate the efficacy of therapy or for patient's management (radiation protection rules and waste disposal). The complex beta counting procedures require extensive sample manipulation during preparation of the liquid scintillation cocktail. The high activity levels that may be found permit one to measure 89Sr activity sample by counting the low yield gamma emission (909 keV) of the radionuclide. However, the contamination of 85Sr due to the reaction for producing 89Sr, if measured with sufficient precision, could be used to evaluate 89Sr activity in urine samples. In other words, the contaminant 85Sr can be used as a tracer of 89Sr. This method was tested in four patients and the accuracy was found to be sufficient to obtain the individual time-activity curves of the urinary excretion.
对接受锶 - 89治疗的患者尿液中的放射性水平进行测量，可用于评估治疗效果或用于患者管理（辐射防护规则和废物处理）。复杂的β计数程序在制备液体闪烁鸡尾酒时需要进行大量的样品处理。所发现的高活性水平使得人们可以通过计数放射性核素的低产率γ发射（909 keV）来测量89Sr活性样品。然而，如果以足够的精度进行测量，由于产生89Sr的反应而导致的85Sr污染可用于评估尿液样品中的89Sr活性。换句话说，污染物85Sr可用作89Sr的示踪剂。该方法在四名患者中进行了测试，发现其准确性足以获得尿液排泄的个体时间 - 活性曲线。
