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锶-89用于治疗前列腺癌引起的疼痛性骨转移。

Strontium-89 for treatment of painful bone metastasis from prostate cancer.

作者信息

Altman G B, Lee C A

机构信息

Department of Physiological Nursing, University of Washington, Seattle, USA.

出版信息

Oncol Nurs Forum. 1996 Apr;23(3):523-7.

PMID:8801513
Abstract

PURPOSE/OBJECTIVE: To review the current use of strontium-89 (89Sr) to treat pain related to bony metastasis secondary to prostate cancer.

DATA SOURCES

Published articles.

DATA SYNTHESIS

Prostate cancer is the most commonly diagnosed cancer in the United States. The disease's most common site of metastasis is the bones. Bone metastasis leads to unrelenting pain. If healthcare providers are able to manage a patient's pain successfully, the patient's quality of life improves.

CONCLUSION

When conventional therapies fail, 89Sr can be used as an alternative or an adjunct to pain management of bony metastasis in prostate cancer.

IMPLICATIONS FOR NURSING PRACTICE

Nursing intervention primarily involves assessing pain, monitoring analgesics until 89Sr can begin to take effect, educating patients on using other medications with 89Sr, and assessing fatigue resulting from 89Sr-induced myelosuppression. As pain decreases, nurses also should monitor patients' activity levels, since they are at risk for pathologic fractures.

摘要

目的/目标:回顾当前锶-89(89Sr)用于治疗前列腺癌继发骨转移相关疼痛的情况。

数据来源

已发表的文章。

数据综合

前列腺癌是美国最常被诊断出的癌症。该疾病最常见的转移部位是骨骼。骨转移会导致持续性疼痛。如果医疗服务提供者能够成功控制患者的疼痛,患者的生活质量将会提高。

结论

当传统疗法无效时,89Sr可作为前列腺癌骨转移疼痛管理的替代或辅助方法。

对护理实践的启示

护理干预主要包括评估疼痛、监测镇痛药直至89Sr开始起效、教育患者如何将89Sr与其他药物联合使用,以及评估89Sr诱导的骨髓抑制所导致的疲劳。随着疼痛减轻,护士还应监测患者的活动水平,因为他们有发生病理性骨折的风险。

相似文献

1
Strontium-89 for treatment of painful bone metastasis from prostate cancer.锶-89用于治疗前列腺癌引起的疼痛性骨转移。
Oncol Nurs Forum. 1996 Apr;23(3):523-7.
2
Use of strontium-89 in endocrine-refractory prostate cancer metastatic to bone. Provincial Genitourinary Cancer Disease Site Group.锶-89在骨转移的内分泌难治性前列腺癌中的应用。省级泌尿生殖系统癌症疾病部位组。
Cancer Prev Control. 1998 Apr;2(2):79-87.
3
[Internal strontium-89 radiotherapy for malignant bony metastasis].
Zhonghua Zhong Liu Za Zhi. 2001 Nov;23(6):507-9.
4
Strontium 89 therapy for the palliation of pain due to osseous metastases.锶89疗法用于缓解骨转移引起的疼痛。
JAMA. 1995 Aug 2;274(5):420-4.
5
Clinical experience with strontium-89 in prostatic and breast cancer patients.
Semin Oncol. 1993 Jun;20(3 Suppl 2):44-8.
6
[Strontium-89: a desirable therapeutic for bone metastases of prostate cancer].[锶-89:前列腺癌骨转移的理想治疗药物]
Zhonghua Nan Ke Xue. 2008 Sep;14(9):819-22.
7
Effects of low-dose cisplatin on 89Sr therapy for painful bone metastases from prostate cancer: a randomized clinical trial.低剂量顺铂对89Sr治疗前列腺癌骨转移疼痛的影响:一项随机临床试验。
J Nucl Med. 2002 Jan;43(1):79-86.
8
Palliation of bone pain in patients with metastatic cancer using strontium-89 (Metastron).使用锶-89(美他生)缓解转移性癌症患者的骨痛
Cancer Nurs. 1995 Aug;18(4):286-91.
9
The treatment of osseous metastases of hormone-refractory prostate cancer with external beam radiotherapy and Strontium-89.激素难治性前列腺癌骨转移的外照射放疗及锶-89治疗
Acta Urol Belg. 1996 Sep;64(3):13-9.
10
Decreased serum E-selectin concentration after 89Sr-chloride therapy for metastatic prostate cancer bone pain.
J Nucl Med. 2000 Jun;41(6):1021-4.

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2
Cardiovascular safety of calcium, magnesium and strontium: what does the evidence say?钙、镁和锶的心血管安全性:证据说了什么?
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3
A review of the latest insights into the mechanism of action of strontium in bone.锶在骨骼中作用机制的最新见解综述。
Bone Rep. 2020 Apr 24;12:100273. doi: 10.1016/j.bonr.2020.100273. eCollection 2020 Jun.