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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Chang F, Wertz P W, Squier C A

Dows Institute for Dental Research, University of Iowa, Iowa City 52242.

Comp Biochem Physiol Comp Physiol. 1993 Jun;105(2):251-3. doi: 10.1016/0300-9629(93)90204-h.

Serial frozen sections (10 microns thick) were cut parallel to the plane of the epithelium from skin, hard palate and gingiva of the pig (Sus scrofa), and beta-glucosidase activity was measured in each section. 2. In each of these tissues, there was a low constitutive level of beta-glucosidase activity in the inner portion of the epithelium, and a several-fold increase in activity was observed in the region of the stratum granulosum-stratum corneum interface. 3. The maximum specific activity of beta-glucosidase was significantly lower in gingiva (8 nmol substrate/hr/slice) than in epidermis and palate (15-18 nmol/hr/slice). 4. The increase in expression of beta-glucosidase activity near the stratum granulosum-stratum corneum boundary appears to be intimately involved in the conversion of glucosylceramides to ceramides in the final stages of differentiation. This conversion may be a major determinant of the barrier properties of the stratum corneum.

从猪（野猪）的皮肤、硬腭和牙龈切取与上皮平面平行的连续冰冻切片（10微米厚），并测定每个切片中的β-葡萄糖苷酶活性。2. 在这些组织的每一个中，上皮内层的β-葡萄糖苷酶活性处于低组成水平，并且在颗粒层-角质层界面区域观察到活性增加了几倍。3. 牙龈中β-葡萄糖苷酶的最大比活性（8纳摩尔底物/小时/切片）明显低于表皮和硬腭（15 - 18纳摩尔/小时/切片）。4. 颗粒层-角质层边界附近β-葡萄糖苷酶活性表达的增加似乎与分化最后阶段葡糖神经酰胺向神经酰胺的转化密切相关。这种转化可能是角质层屏障特性的主要决定因素。

Chang F, Wertz P W, Squier C A

Dows Institute for Dental Research, University of Iowa, Iowa City 52242.

Comp Biochem Physiol Comp Physiol. 1993 Jun;105(2):251-3. doi: 10.1016/0300-9629(93)90204-h.

Serial frozen sections (10 microns thick) were cut parallel to the plane of the epithelium from skin, hard palate and gingiva of the pig (Sus scrofa), and beta-glucosidase activity was measured in each section. 2. In each of these tissues, there was a low constitutive level of beta-glucosidase activity in the inner portion of the epithelium, and a several-fold increase in activity was observed in the region of the stratum granulosum-stratum corneum interface. 3. The maximum specific activity of beta-glucosidase was significantly lower in gingiva (8 nmol substrate/hr/slice) than in epidermis and palate (15-18 nmol/hr/slice). 4. The increase in expression of beta-glucosidase activity near the stratum granulosum-stratum corneum boundary appears to be intimately involved in the conversion of glucosylceramides to ceramides in the final stages of differentiation. This conversion may be a major determinant of the barrier properties of the stratum corneum.

从猪（野猪）的皮肤、硬腭和牙龈切取与上皮平面平行的连续冰冻切片（10微米厚），并测定每个切片中的β-葡萄糖苷酶活性。2. 在这些组织的每一个中，上皮内层的β-葡萄糖苷酶活性处于低组成水平，并且在颗粒层-角质层界面区域观察到活性增加了几倍。3. 牙龈中β-葡萄糖苷酶的最大比活性（8纳摩尔底物/小时/切片）明显低于表皮和硬腭（15 - 18纳摩尔/小时/切片）。4. 颗粒层-角质层边界附近β-葡萄糖苷酶活性表达的增加似乎与分化最后阶段葡糖神经酰胺向神经酰胺的转化密切相关。这种转化可能是角质层屏障特性的主要决定因素。