Skvortsov S V, Kalinin A V, Lytsar' B N
Vestn Ross Akad Med Nauk. 1993(4):47-9.
Enzyme immunoassay was used to study blood levels of CA-19-9, cancerous embryonal antigen, and alpha-fetoprotein in blood donors (n = 33), patients with chronic pancreatitis (n = 35), those with pancreatic carcinoma with metastases (n = 28), and without them (n = 21). A differential diagnosis was found to be made between healthy individuals and patients with chronic pancreatitis and those with pancreatic carcinoma via determination of the above tumour markers. The presence of hepatic metastases of pancreatic carcinoma may be suspected if the blood levels of the cancerous embryonal antigen and CA-19-9 are over 15 ng/ml and over 600 U/ml. The level of alpha-fetoprotein was higher only in 14.3% of pancreatic carcinoma patients with hepatic metastases. A comprehensive examination of the levels of all three tumor markers allows one to differentiate pancreatic carcinoma and chronic pancreatitis and to determine whether a patient with pancreatic carcinoma is operable.
采用酶免疫分析法研究了献血者（n = 33）、慢性胰腺炎患者（n = 35）、伴有转移的胰腺癌患者（n = 28）和无转移的胰腺癌患者（n = 21）血液中CA - 19 - 9、癌胚抗原和甲胎蛋白的水平。通过测定上述肿瘤标志物，发现可以对健康个体、慢性胰腺炎患者和胰腺癌患者进行鉴别诊断。如果癌胚抗原和CA - 19 - 9的血液水平分别超过15 ng/ml和600 U/ml，则可能怀疑存在胰腺癌肝转移。仅14.3%的伴有肝转移的胰腺癌患者甲胎蛋白水平升高。综合检测所有三种肿瘤标志物的水平有助于鉴别胰腺癌和慢性胰腺炎，并确定胰腺癌患者是否可进行手术。
