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Cyclic AMP inhibits c-Ha-ras protooncogene expression and DNA synthesis in rat aortic smooth muscle cells.

作者信息

Sadhu D N, Ramos K S

机构信息

Department of Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station 77843-4466.

出版信息

Experientia. 1993 Jul 5;49(6-7):567-70. doi: 10.1007/BF01955165.

DOI:10.1007/BF01955165
PMID:7687563
Abstract

Fetal bovine serum (10%) markedly increased ras transcript levels in growth-arrested (G0-synchronized) smooth muscle cells by 8 h. This elevation was maintained for up to 18 h and returned to pre-stimulation levels within 24 h. Challenge of quiescent cells with serum in the presence of dibutyryl cyclic AMP (1-100 microM, a growth inhibitor for smooth muscle cells, attenuated serum-induced elevation of c-Ha-ras in a dose dependent fashion and prevented progression of the cells into S phase. These results demonstrate that expression of c-Ha-ras in rat aortic smooth muscle cells is cell-cycle dependent and that cAMP prevents the induction of this protooncogene by serum.

摘要

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本文引用的文献

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Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation.化学转化后，c-myc的细胞周期控制丧失，但c-ras的表达未受影响。
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A method for staining 3T3 cell nuclei with propidium iodide in hypotonic solution.一种在低渗溶液中用碘化丙啶对3T3细胞核进行染色的方法。
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Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells.NIH 3T3细胞血清刺激生长过程中ras原癌基因功能的需求
H-RAS 控制血管平滑肌细胞的表型特征以及血管增殖性疾病的发病机制。
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Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells.二丁酰环磷腺苷处理的HL-60细胞中c-myc和转铁蛋白受体的转录失活
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.采用酸性硫氰酸胍-苯酚-氯仿萃取法一步分离RNA的方法。
Anal Biochem. 1987 Apr;162(1):156-9. doi: 10.1006/abio.1987.9999.
8
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