利用酿酒酵母mnn突变体对念珠菌因子1和9抗血清识别的表位进行鉴定。
Characterization of epitopes recognized by Candida factor 1 and 9 antisera by use of Saccharomyces cerevisiae mnn mutants.
作者信息
Ataoglu H, Zueco J, Sentandreu R
机构信息
Departamento de Microbiología, Facultat de Farmàcia, Universitat de València, Burjassot, Spain.
出版信息
Infect Immun. 1993 Aug;61(8):3313-7. doi: 10.1128/iai.61.8.3313-3317.1993.
Abstract
The use of Saccharomyces cerevisiae mnn mutants has facilitated the study of the epitopes recognized by antisera against several antigenic factors of the genus Candida (Candida Check; Iatron Laboratories, Tokyo, Japan). We have taken advantage of the very well characterized structure of the mannans of the different mnn mutants to compare their reactivities with the factor antisera used in the identification of different species of the genus Candida. The results of this study provide evidence that one of the antigenic determinants recognized by factor 1 antisera is the O-linked mannose chains of the cell wall mannoproteins, while that recognized by factor 9 antiserum is the alpha 1-6-linked mannose backbone of the outer chain of the N-linked oligosaccharide.
摘要
酿酒酵母mnn突变体的使用促进了针对念珠菌属几种抗原因子的抗血清所识别表位的研究（念珠菌检测；日本东京医创株式会社）。我们利用不同mnn突变体甘露聚糖特征明确的结构，比较它们与用于鉴定念珠菌属不同菌种的因子抗血清的反应性。这项研究结果表明，因子1抗血清识别的抗原决定簇之一是细胞壁甘露糖蛋白的O-连接甘露糖链，而因子9抗血清识别的是N-连接寡糖外链的α1-6连接甘露糖主链。
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本文引用的文献
1
A method for the rapid identification of the genus Candida.一种快速鉴定念珠菌属的方法。
Mycopathol Mycol Appl. 1959 Mar 31;10(3):191-206. doi: 10.1007/BF02053014.
2
Fungitoxicity of muramidase. Ultrastructural damage to Candida albicans.溶菌酶的抗真菌毒性。白色念珠菌的超微结构损伤。
Lab Invest. 1982 Jun;46(6):627-36.
3
Comparative evaluation of the Iatron serological Candida check kit and the API 20C kit for identification of medically important Candida species.Iatron血清学念珠菌检测试剂盒与API 20C试剂盒用于鉴定医学上重要念珠菌属菌种的比较评估。
J Clin Microbiol. 1981 Mar;13(3):513-8. doi: 10.1128/jcm.13.3.513-518.1981.
4
Saccharomyces cerevisiae mutants that make mannoproteins with a truncated carbohydrate outer chain.酿酒酵母突变体，其产生具有截短碳水化合物外链的甘露糖蛋白。
J Biol Chem. 1980 Jun 25;255(12):5986-91.
5
Adherence of Candida albicans to buccal and vaginal epithelial cells: ultrastructural observations.白色念珠菌对颊黏膜和阴道上皮细胞的黏附：超微结构观察
Can J Microbiol. 1984 Aug;30(8):1001-7. doi: 10.1139/m84-156.
6
Significance of serological studies on yeasts.酵母血清学研究的意义。
Mycopathol Mycol Appl. 1965 Jun 15;26(1):1-15. doi: 10.1007/BF02098585.
7
The structure of a glycopeptide isolated from the yeast cell wall.从酵母细胞壁中分离出的一种糖肽的结构。
Biochem J. 1968 Sep;109(3):419-32. doi: 10.1042/bj1090419.
8
Application of agglutinins for the rapid and accurate identification of medically important Candida species.凝集素在快速准确鉴定医学上重要念珠菌属物种中的应用。
Appl Microbiol. 1970 May;19(5):830-6. doi: 10.1128/am.19.5.830-836.1970.
9
Serologic aspects on yeast classification.酵母分类的血清学方面
Mycopathol Mycol Appl. 1974 Aug 30;53(1):77-91. doi: 10.1007/BF02127199.
10
Genetic control of yeast mannan structure. Isolation and characterization of mannan mutants.酵母甘露聚糖结构的遗传控制。甘露聚糖突变体的分离与鉴定。
J Biol Chem. 1973 Jul 10;248(13):4660-6.
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