Schönberger J P, Bredée J J, van Oeveren W, van Zundert A A, Verkroost M, Terwoorst J, Bavinck J H, Berreklouw E, Wildevuur C R
Department of Cardiopulmonary Surgery, Catharina Hospital, Eindhoven, The Netherlands.
J Thorac Cardiovasc Surg. 1993 Aug;106(2):262-7.
The effect of preoperative low-dose aspirin (1 mg/kg of body weight) and intraoperative low-dose aprotinin (2 million kallikrein inactivator units) treatment on perioperative blood loss and blood requirements in patients who undergo internal mammary artery bypass operations is unknown. Therefore, we retrospectively studied 75 matching patients who underwent internal mammary artery operations, and they were allocated to one of three groups: low-dose aspirin and aprotinin treatment (group 1, n = 25), low-dose aspirin treatment without aprotinin (group 2, n = 25), and neither aspirin nor aprotinin treatment (group 3, n = 25). Although the perioperative blood loss was similar, the blood requirements tended to be higher (p = 0.09) in the patients who were treated with aspirin (group 2) than in the control patients (group 3). When aprotinin was added to the priming solution in patients who were treated with aspirin (group 1), blood loss was significantly lower (p < 0.05) than that of group 2 patients but not of control patients. Blood requirements were significantly lower (p < 0.01) than those of patients in groups 2 and 3. Blood products were needed in 29%, 62%, and 75% of patients in groups 1, 2, and 3, respectively.
术前低剂量阿司匹林（1毫克/千克体重）和术中低剂量抑肽酶（200万激肽释放酶灭活单位）治疗对接受乳内动脉搭桥手术患者围手术期失血量和血液需求量的影响尚不清楚。因此，我们回顾性研究了75例接受乳内动脉手术的匹配患者，他们被分为三组之一：低剂量阿司匹林和抑肽酶治疗组（第1组，n = 25）、仅低剂量阿司匹林治疗组（第2组，n = 25）以及既不使用阿司匹林也不使用抑肽酶治疗组（第3组，n = 25）。尽管围手术期失血量相似，但接受阿司匹林治疗的患者（第2组）的血液需求量往往高于对照组患者（第3组）（p = 0.09）。当在接受阿司匹林治疗的患者（第1组）的预充液中加入抑肽酶时，失血量显著低于第2组患者（p < 0.05），但与对照组患者无差异。血液需求量显著低于第2组和第3组患者（p < 0.01）。第1、2、3组分别有29%、62%和75%的患者需要输血。
