氯氮平所致粒细胞缺乏症与集落刺激细胞因子

Clozapine-induced agranulocytosis and colony-stimulating cytokines.

作者信息

Ryabik B M, Nguyen V T, Mann R M, Smith J D, Lippmann S B

机构信息

Department of Psychiatry and Behavioral Sciences, University of Louisville, School of Medicine, Kentucky.

出版信息

Gen Hosp Psychiatry. 1993 Jul;15(4):263-5. doi: 10.1016/0163-8343(93)90042-m.

DOI:10.1016/0163-8343(93)90042-m

PMID:7688331

Abstract

A case of clozapine-induced agranulocytosis that was treated with a granulocyte colony-stimulating cytokine is presented. The hematological status normalized. Two colony-stimulating factors are marketed for activating bone marrow function. Their utility in clozapine a granulocytoses is not clear, but they offer a potential new therapeutic option.

摘要

本文介绍了一例使用粒细胞集落刺激细胞因子治疗氯氮平所致粒细胞缺乏症的病例。血液学状态恢复正常。有两种集落刺激因子已上市用于激活骨髓功能。它们在氯氮平所致粒细胞缺乏症中的效用尚不清楚，但提供了一种潜在的新治疗选择。