Thiry A, Delvenne P, Fontaine M A, Boniver J
Department of Pathology, University of Liège, Belgium.
Histopathology. 1993 May;22(5):423-8. doi: 10.1111/j.1365-2559.1993.tb00155.x.
Bone marrow specimens from 118 patients with clinical suspicion of multiple myeloma were studied to assess the diagnostic reliability of histological and cytological criteria. Plasma cell clonality was assessed by demonstrating light chain restriction. In most cases of multiple myeloma, the classical cytological and histological criteria were found. In eight cases in which the marrow contained less than 10% of plasma cells, there was discordance between the light microscopic and immunohistochemical findings. In six cases without evidence of multiple myeloma and with polyclonal plasma cells in bone marrow, abnormal plasma cells resembling a malignant proliferation were found. These findings indicate that comparison of histological and cytological results with immunohistological studies for immunoglobulin light chains in bone marrow biopsy sections can be helpful in the evaluation of patients with a suspicion of multiple myeloma and when the marrow contains less than 10% of plasma cells.
对118例临床疑似多发性骨髓瘤患者的骨髓标本进行研究，以评估组织学和细胞学标准的诊断可靠性。通过显示轻链限制来评估浆细胞克隆性。在大多数多发性骨髓瘤病例中，发现了经典的细胞学和组织学标准。在8例骨髓浆细胞少于10%的病例中，光镜和免疫组化结果不一致。在6例无多发性骨髓瘤证据且骨髓中浆细胞为多克隆性的病例中，发现了类似恶性增殖的异常浆细胞。这些发现表明，在骨髓活检切片中，将组织学和细胞学结果与免疫球蛋白轻链的免疫组织学研究结果进行比较，有助于评估疑似多发性骨髓瘤且骨髓浆细胞少于10%的患者。
