Mac Manus M P, Clarke J, McCormick D, Abram W P
Northern Ireland Center for Clinical Oncology, Belvoir Park Hospital, Belfast.
Int J Radiat Oncol Biol Phys. 1993 Aug 1;26(5):845-50. doi: 10.1016/0360-3016(93)90500-u.
To investigate the effectiveness of recombinant human Granulocyte-Colony Stimulating Factor, a hematopoietic growth factor which stimulates neutrophil production, in the treatment of neutropenia caused by Craniospinal Irradiation.
Four consecutive patients who developed neutropenia (neutrophils less than 1.5 X 10(9)/l in peripheral blood) during craniospinal irradiation for primary intracranial tumors received intermittent subcutaneous injections of Granulocyte-Colony Stimulating Factor. Two of the patients had medulloblastoma, one had a primitive neuroectodermal tumor and the other a pinealocytoma. No patient received prior or concurrent chemotherapy.
In all cases peripheral blood neutrophil counts returned rapidly to normal levels following Granulocyte-Colony Stimulating Factor injections and treatment delays were therefore avoided. Platelet counts were unaffected by Granulocyte Colony Stimulating Factor treatment. In one case, slight elevation of peripheral blood monocyte and lymphocyte counts occurred after each Granulocyte-Colony Stimulating Factor injection. No toxicity was encountered.
Our results suggest that Granulocyte-Colony Stimulating Factor is a safe and effective treatment for neutropenia caused by extended field radiotherapy.
研究重组人粒细胞集落刺激因子（一种刺激中性粒细胞生成的造血生长因子）治疗颅脊髓照射所致中性粒细胞减少症的有效性。
4例原发性颅内肿瘤患者在颅脊髓照射期间出现中性粒细胞减少症（外周血中性粒细胞低于1.5×10⁹/L），接受了粒细胞集落刺激因子的间歇性皮下注射。其中2例为髓母细胞瘤，1例为原始神经外胚层肿瘤，另1例为松果体细胞瘤。所有患者均未接受过先前或同期化疗。
所有病例在注射粒细胞集落刺激因子后外周血中性粒细胞计数迅速恢复至正常水平，从而避免了治疗延误。血小板计数不受粒细胞集落刺激因子治疗的影响。1例患者在每次注射粒细胞集落刺激因子后外周血单核细胞和淋巴细胞计数略有升高。未发现毒性反应。
我们的结果表明，粒细胞集落刺激因子是治疗扩大野放疗所致中性粒细胞减少症的一种安全有效的方法。
