Ogonor J I
Department of Pharmaceutic Chemistry, Faculty of Pharmacy, University of Benin, Nigeria.
J Clin Pharm Ther. 1993 Jun;18(3):209-11. doi: 10.1111/j.1365-2710.1993.tb00615.x.
Five healthy male volunteers participated in this study, after informed consent, to determine the effect of chloroquine administration on plasma albumin, bilirubin, amylase, alkaline phosphatase and blood urea. Each subject took 600 mg of chloroquine base (i.e. four tablets containing a 150-mg base per tablet) and blood samples were obtained over a 7-day period. The plasma samples were assayed for albumin, bilirubin, amylase, alkaline phosphatase and blood urea. Results indicate that at the dose used chloroquine administration does not produce any significant change in the plasma levels of albumin and bilirubin. However, serum amylase and urea were decreased while alkaline phosphatase was increased by the chloroquine treatment. These changes are of no clinical significance as the new values are within the normal ranges.
五名健康男性志愿者在签署知情同意书后参与了本研究，以确定服用氯喹对血浆白蛋白、胆红素、淀粉酶、碱性磷酸酶和血尿素的影响。每名受试者服用600毫克氯喹碱（即四片每片含150毫克碱的片剂），并在7天内采集血样。对血浆样本进行白蛋白、胆红素、淀粉酶、碱性磷酸酶和血尿素检测。结果表明，在所使用的剂量下，服用氯喹不会使血浆白蛋白和胆红素水平产生任何显著变化。然而，氯喹治疗使血清淀粉酶和尿素水平降低，而碱性磷酸酶水平升高。这些变化不具有临床意义，因为新的值仍在正常范围内。
