逆转录病毒变异与逆转录：异常链转移导致逆转录病毒基因变异。
Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.
作者信息
Temin H M
机构信息
McArdie Laboratory, University of Wisconsin, Madison 53706.
出版信息
Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6900-3. doi: 10.1073/pnas.90.15.6900.
Abstract
Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.
摘要
人类免疫缺陷病毒变异广泛，且基于逆转录过程中的众多错误。所有逆转录病毒的复制都需要两次链转移（生长点跳跃）来合成完整的前病毒。我认为逆转录过程中的众多错误是形成前病毒所需的两次链转移这一要求的结果。
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