Jenkins M K, Johnson J G
Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455.
Curr Opin Immunol. 1993 Jun;5(3):361-7. doi: 10.1016/0952-7915(93)90054-v.
Maximal expression of the interleukin-2 gene in T cells depends on biochemical signals in addition to those transduced by the T cell antigen receptor. Recent work indicates that the T-cell specific molecule CD28 transduces a 'costimulatory' signal when it binds its ligand, the B7 molecule, on the surface of an antigen-presenting cell. Results from experiments performed during the past year have raised the exciting possibility that immune responses can be either inhibited or augmented by manipulation of the CD28-B7 interaction.
T细胞中白细胞介素-2基因的最大表达除了依赖于T细胞抗原受体转导的信号外，还取决于生化信号。最近的研究表明，T细胞特异性分子CD28在与抗原呈递细胞表面的配体B7分子结合时，会转导一种“共刺激”信号。过去一年进行的实验结果提出了一个令人兴奋的可能性，即通过操纵CD28-B7相互作用，可以抑制或增强免疫反应。
