Hogg N, Landis R C
Imperial Cancer Research Fund, London, UK.
Curr Opin Immunol. 1993 Jun;5(3):383-90. doi: 10.1016/0952-7915(93)90057-y.
During a successful immune response, several families of adhesion molecules participate in a cascade of binding events that lead to the binding of leukocytes, both to each other and to cell types such as the endothelium and epithelium. A central theme emerging from recent studies is that the function of an adhesion receptor cannot be inferred from its expression alone; rather, adhesion receptors are 'selected' to perform distinct effector functions based on their cell-background and factors present in the local microenvironment. Thus, adhesion receptors expressed on different cell-types may find themselves in different states of 'activation-readiness' and may be further selected by prevailing conditions in the microenvironment to bind tissue-specific ligands and mediate leukocyte effector functions such as homing or transendothelial migration.
在成功的免疫反应过程中，几个黏附分子家族参与一系列结合事件，这些事件导致白细胞彼此之间以及与内皮细胞和上皮细胞等细胞类型的结合。最近研究中出现的一个核心观点是，不能仅从黏附受体的表达来推断其功能；相反，黏附受体是根据其细胞背景和局部微环境中存在的因素“被选择”来执行不同的效应功能。因此，在不同细胞类型上表达的黏附受体可能处于不同的“激活准备”状态，并且可能会被微环境中的主要条件进一步选择，以结合组织特异性配体并介导白细胞效应功能，如归巢或跨内皮迁移。
