Offit K, Parsa N Z, Jhanwar S C, Filippa D, Wachtel M, Chaganti R S
Laboratory of Cancer Genetics, Sloan-Kettering Institute, New York, NY 10021.
Genes Chromosomes Cancer. 1993 May;7(1):1-7. doi: 10.1002/gcc.2870070102.
In this study we analyzed nonrandom aberrations affecting chromosome 9 in a series of 426 consecutively ascertained, karyotypically abnormal non-Hodgkin's lymphoma (NHL) tumors derived from 407 patients. Cytogenetic abnormalities were correlated with clinical, histologic, and immunologic features. Structural abnormalities of chromosome 9 were identified in 60 specimens derived from 59 patients. The recurring abnormalities among these were associated with 4 clinico-pathologic subsets. The first comprised 7 cases of t(9;14)(p13;q32), 6 of which had small lymphocytic lymphoma, plasmacytoid subtype, and an indolent clinical course. The second group included 12 cases with breaks at 9q11-13 and diffuse lymphomas with a large-cell component and a typical response to combination chemotherapy. The third group was comprised of 7 cases with 9q deletions, with a common deleted region encompassing 9q31-32. These cases were characterized by diffuse B-cell histology, young age, and poor clinical outcome. The fourth subset included 5 intermediate- to high-grade T-cell tumors with breaks at 9q34. This analysis of chromosome 9 aberrations in NHL comprises the first such effort based on a large series of tumors. We identify and report here new clinico-pathologic subsets with shared abnormalities of chromosome 9, which should facilitate new approaches to the analysis of the etiology and clinical behavior of NHL.
在本研究中，我们分析了一系列426例连续确诊的、核型异常的非霍奇金淋巴瘤（NHL）肿瘤中影响9号染色体的非随机畸变，这些肿瘤来自407例患者。细胞遗传学异常与临床、组织学和免疫学特征相关。在来自59例患者的60个标本中发现了9号染色体的结构异常。这些复发性异常与4个临床病理亚组相关。第一组包括7例t(9;14)(p13;q32)，其中6例为小淋巴细胞淋巴瘤，浆细胞样亚型，临床病程惰性。第二组包括12例9q11 - 13断裂的病例，为具有大细胞成分的弥漫性淋巴瘤，对联合化疗有典型反应。第三组由7例9q缺失的病例组成，常见的缺失区域包括9q31 - 32。这些病例的特征为弥漫性B细胞组织学、年轻且临床预后差。第四亚组包括5例9q34断裂的中高级别T细胞肿瘤。对NHL中9号染色体畸变的这一分析是基于大量肿瘤的首次此类研究。我们在此识别并报告了具有9号染色体共同异常的新临床病理亚组，这应有助于分析NHL病因和临床行为的新方法。
