Simbirtsev A S, Pigareva V G, Kalinina N M, Sorokin E M, Ketlinskiĭ S A
Vestn Ross Akad Med Nauk. 1993(2):18-22.
Human recombinant IL-1 beta injected intraperitoneally into CBA mice dose-dependently induced leukocytosis, stimulated phagocytosis and reduced tetrazolium nitroblue by peritoneal leukocytes, colony formation by bone marrow cells, enhanced Con A and IL-2-induced proliferation and IL-2 production in thymocytes and splenocytes. Recombinant IL-1 beta restored bone marrow cell proliferation reduced after 5-fluorouracil treatment and significantly increased the survival rates of lethally irradiated mice.
将人重组白细胞介素-1β腹腔注射到CBA小鼠体内，可剂量依赖性地诱导白细胞增多，刺激吞噬作用，并使腹腔白细胞还原硝基蓝四氮唑，使骨髓细胞集落形成减少，增强刀豆蛋白A和白细胞介素-2诱导的胸腺细胞和脾细胞增殖以及白细胞介素-2的产生。重组白细胞介素-1β可恢复5-氟尿嘧啶治疗后降低的骨髓细胞增殖，并显著提高受致死性照射小鼠的存活率。
