Joujou-Sisic K, Granérus M, Wetterling H, Wikström K, Engström W, Jeffcott L, Schofield P N, Welin A
Department of Pathology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
Cell Biol Int. 1993 Jun;17(6):603-7. doi: 10.1006/cbir.1993.1105.
The expression of the insulin like growth factor (IGF) II gene has been examined in the developing equine fetus. It was found that IGF II transcripts were present in abundant quantities in third trimester embryonic and extraembryonic tissues as for example the placenta. The expression of the IGF II gene was high in the fetal liver where two prominent transcripts--4.6 and 4.1--kB were produced. However, these transcripts could not be traced in the adult liver. Instead we found two different transcripts with the sizes of 4.0 and 2.9 kB in the adult liver. These findings taken together with the demonstration of heterologous IGF II cDNA hybridizing to equine DNA-digests suggests that the IGF II gene is under developmental control in the horse, with the possible existence of different promoters.
在发育中的马胎儿中对胰岛素样生长因子（IGF）II基因的表达进行了研究。结果发现，在妊娠晚期的胚胎和胚外组织（如胎盘）中，IGF II转录本大量存在。IGF II基因在胎儿肝脏中高表达，产生了两种显著的转录本——4.6和4.1千碱基。然而，在成年肝脏中无法追踪到这些转录本。相反，我们在成年肝脏中发现了两种大小分别为4.0和2.9千碱基的不同转录本。这些发现，再加上异源IGF II cDNA与马DNA消化物杂交的证明，表明IGF II基因在马中受到发育调控，可能存在不同的启动子。
