丙型肝炎病毒性传播风险低。

Low risk of sexual transmission of hepatitis C virus.

作者信息

Hallam N F, Fletcher M L, Read S J, Majid A M, Kurtz J B, Rizza C R

机构信息

Virology Department, Public Health Laboratory, John Radcliffe Hospital, Oxford, England.

出版信息

J Med Virol. 1993 Jul;40(3):251-3. doi: 10.1002/jmv.1890400315.

DOI:10.1002/jmv.1890400315

PMID:7689092

Abstract

Sexual transmission of hepatitis C virus (HCV) was studied between 104 anti-HCV positive index cases (99 haemophilic men, five women) who have attended the Oxford Haemophilia Centre and 104 (98 female, 6 male) longstanding sexual partners. Ninety-one percent of the index cases were HCV RNA positive by the polymerase chain reaction (PCR) and 56% were anti-human immunodeficiency virus (HIV) positive. Three (2.9%) sexual partners (each a female partner of a different HCV RNA positive haemophilic man) were anti-HCV, and HCV RNA, positive. All had other risk factors for HCV infection. Of 59 partners who were tested for anti-HIV four (7%) were positive and only one of these was also anti-HCV positive. There was no association between HIV positivity in the index cases and HCV positivity in their partners. Our results confirm a low risk of sexual transmission of HCV.

摘要

对牛津血友病中心的104例抗丙型肝炎病毒（HCV）阳性的索引病例（99例男性血友病患者，5例女性）及其104名（98名女性，6名男性）长期性伴侣之间丙型肝炎病毒的性传播情况进行了研究。通过聚合酶链反应（PCR）检测，91%的索引病例HCV RNA呈阳性，56%的病例抗人类免疫缺陷病毒（HIV）呈阳性。3名（2.9%）性伴侣（均为不同的HCV RNA阳性男性血友病患者的女性伴侣）抗HCV及HCV RNA均呈阳性。所有这些性伴侣均有其他丙型肝炎病毒感染的危险因素。在59名接受抗HIV检测的性伴侣中，4名（7%）呈阳性，其中只有1名同时抗HCV也呈阳性。索引病例中的HIV阳性与其性伴侣中的HCV阳性之间无关联。我们的结果证实丙型肝炎病毒的性传播风险较低。