Healey C J, Smith D B, Walker J L, Holmes E C, Fleming K A, Chapman R W, Simmonds P
Department of Gastroenterology, John Radcliffe Hospital, Oxford.
Gut. 1995 Jan;36(1):148-50. doi: 10.1136/gut.36.1.148.
A case is described of a woman with acute hepatitis C infection whose partner had chronic hepatitis C infection and where heterosexual contact was the only major risk factor. Infection of both partners was confirmed serologically and by the finding of virus RNA by reverse transcription and polymerase chain reaction amplification. Nucleotide sequence analysis of the NS5 region (RNA polymerase) was used to show that both partners were infected with virus of the same genotype (1a). The nucleotide sequence of virus RNA found in the female patient is closest to variants cocirculating in the male contact, consistent with transmission having occurred between the two.
本文描述了一例急性丙型肝炎感染女性病例，其伴侣为慢性丙型肝炎感染，异性接触是唯一的主要危险因素。通过血清学检测以及逆转录和聚合酶链反应扩增发现病毒RNA，证实了双方均被感染。对NS5区域（RNA聚合酶）进行核苷酸序列分析，结果显示双方感染的病毒属于同一基因型（1a）。在女性患者体内发现的病毒RNA核苷酸序列与男性接触者体内共同传播的病毒变体最为接近，这与病毒在两人之间传播的情况相符。
