Veys E M, Mielants H
Department of Rheumatology, University Hospital, Ghent, Belgium.
Curr Opin Rheumatol. 1993 Jul;5(4):420-7. doi: 10.1097/00002281-199305040-00004.
Enteropathic arthritides, uveitis, and Whipple's disease all belong to the category of spondyloarthropathies. The exact mechanism of relationships among joint, tendon, and axial involvement in the spondyloarthropathies, and gut and eye involvement, is unsolved. Different hypotheses have been proposed to explain the role of enterogenic bacteria in interfering with the HLA system and causing inflammatory reactions in these organs. The microorganism responsible for Whipple's disease (Tropheryma whippelii) has been identified by sequencing the largest part of a bacterial 16S ribosomal RNA, followed by polymerase chain reaction amplification. Late-onset pauciarticular juvenile chronic arthritis should be included in the category of the spondyloarthropathies. New cases of ankylosing spondylitis associated with diffuse idiopathic skeletal hyperostosis have been reported.
肠病性关节炎、葡萄膜炎和惠普尔病都属于脊柱关节病范畴。脊柱关节病中关节、肌腱及中轴受累与肠道和眼部受累之间的确切关系机制尚未明确。已提出不同假说来解释肠道源性细菌在干扰HLA系统及引发这些器官炎症反应中所起的作用。通过对细菌16S核糖体RNA的大部分进行测序，随后进行聚合酶链反应扩增，已鉴定出导致惠普尔病的微生物（惠普尔氏嗜组织细胞菌）。迟发性少关节型幼年慢性关节炎应归入脊柱关节病范畴。已有报告称出现了与弥漫性特发性骨肥厚相关的强直性脊柱炎新病例。
