Bakhitova L M, Drobchenko S N
Izv Akad Nauk Ser Biol. 1993 Jul-Aug(4):613-7.
The effects of dextran + hydrazine or amino derivative of dibunol and of dextran + cystafos derivatives with different degree of modification of their molecules on the mutagenic activity of gamma irradiation were studied using the micronucleus test in polychromatophilic erythrocytes of the mouse bone marrow. The effects of these compounds on differentiation of the erythroid series has also been studied. The mutagenic activity of gamma irradiation was most markedly inhibited by the copolymer dextran and the amino derivative dibunol. The optimal structure of copolymers was 1 heterocyclic link per 3 non-oxidized links of dextran, while the increasing number of active links in the dextran molecule insignificantly enhanced its antimutagenic effect. The studied compounds effectively protected erythropoiesis.
使用小鼠骨髓嗜多染红细胞微核试验，研究了葡聚糖+肼或二丁诺尔氨基衍生物以及分子修饰程度不同的葡聚糖+胱胺磷衍生物对γ射线诱变活性的影响。还研究了这些化合物对红细胞系分化的影响。γ射线的诱变活性受到共聚物葡聚糖和二丁诺尔氨基衍生物的最显著抑制。共聚物的最佳结构是每3个未氧化的葡聚糖链节有1个杂环链节，而葡聚糖分子中活性链节数量的增加对其抗诱变作用的增强不明显。所研究的化合物有效地保护了红细胞生成。
