HLA - DRW2与抗体介导的肺出血肾炎综合征之间存在强关联。
Strong association between HLA-DRW2 and antibody-mediated Goodpasture's syndrome.
作者信息
Rees A J, Peters D K, Compston D A, Batchelor J R
出版信息
Lancet. 1978 May 6;1(8071):966-8. doi: 10.1016/s0140-6736(78)90252-0.
PMID:76894
Abstract
In a study of HLA types in Caucasian patients with nephritis due to antibodies to glomerular basement membrane, antigen frequencies at A, B, or CW loci were normal. However, 15 out of 17 (88%) patients to whom DRW types were definitely assigned had HLA-DRW2 compared with 32 out of 100 Caucasian blood-donors. This difference is highly significant.
摘要
在一项针对因抗肾小球基底膜抗体导致肾炎的白种患者的HLA类型研究中，A、B或CW位点的抗原频率正常。然而，在明确确定了DRW类型的17名患者中，有15名（88%）具有HLA - DRW2，而在100名白种献血者中只有32名具有该类型。这种差异具有高度显著性。
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