• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

HLA - DRW2与抗体介导的肺出血肾炎综合征之间存在强关联。

Strong association between HLA-DRW2 and antibody-mediated Goodpasture's syndrome.

作者信息

Rees A J, Peters D K, Compston D A, Batchelor J R

出版信息

Lancet. 1978 May 6;1(8071):966-8. doi: 10.1016/s0140-6736(78)90252-0.

DOI:10.1016/s0140-6736(78)90252-0
PMID:76894
Abstract

In a study of HLA types in Caucasian patients with nephritis due to antibodies to glomerular basement membrane, antigen frequencies at A, B, or CW loci were normal. However, 15 out of 17 (88%) patients to whom DRW types were definitely assigned had HLA-DRW2 compared with 32 out of 100 Caucasian blood-donors. This difference is highly significant.

摘要

在一项针对因抗肾小球基底膜抗体导致肾炎的白种患者的HLA类型研究中,A、B或CW位点的抗原频率正常。然而,在明确确定了DRW类型的17名患者中,有15名(88%)具有HLA - DRW2,而在100名白种献血者中只有32名具有该类型。这种差异具有高度显著性。

相似文献

1
Strong association between HLA-DRW2 and antibody-mediated Goodpasture's syndrome.HLA - DRW2与抗体介导的肺出血肾炎综合征之间存在强关联。
Lancet. 1978 May 6;1(8071):966-8. doi: 10.1016/s0140-6736(78)90252-0.
2
[Glomerular basement membrane antibodies and immune complexes in a patient with Goodpasture's syndrome].[一名患有肺出血肾炎综合征患者的肾小球基底膜抗体和免疫复合物]
Pol Tyg Lek. 1980 Apr 14;35(15):539-40.
3
A single autoantigen in Goodpasture's syndrome identified by a monoclonal antibody to human glomerular basement membrane.通过针对人肾小球基底膜的单克隆抗体鉴定出的Goodpasture综合征中的单一自身抗原。
Lab Invest. 1987 Jan;56(1):23-31.
4
Goodpasture's syndrome in a patient with the Nail-Patella syndrome.一名患有指甲-髌骨综合征的患者出现了肺出血肾炎综合征。
Am J Med. 1976 Sep;61(3):401-6. doi: 10.1016/0002-9343(76)90378-8.
5
The Goodpasture antigen in Alport's syndrome: studies with a monoclonal antibody.阿尔波特综合征中的Goodpasture抗原:单克隆抗体研究
Kidney Int. 1986 Jul;30(1):107-12. doi: 10.1038/ki.1986.158.
6
The evolution of crescentic nephritis and alveolar haemorrhage following induction of autoimmunity to glomerular basement membrane in an experimental model of Goodpasture's disease.在古德帕斯彻氏病实验模型中,诱导针对肾小球基底膜的自身免疫后新月体性肾炎和肺泡出血的演变。
J Pathol. 2003 May;200(1):118-29. doi: 10.1002/path.1336.
7
Goodpasture's syndrome--a case report.肺出血肾炎综合征——病例报告
Changgeng Yi Xue Za Zhi. 1990 Jun 20;13(2):143-51.
8
Immunologic and electron microscopic studies in Goodpasture's syndrome.古德帕斯彻综合征的免疫学与电子显微镜研究。
Am J Med. 1970 Aug;49(2):250-7. doi: 10.1016/s0002-9343(70)80081-x.
9
[Goodpasture's syndrome. Observations on a case].
Minerva Med. 1978 May 19;69(25):1749-59.
10
Pathogenicity of anti-basement membrane (NC1) antibodies: an experimental Goodpasture's syndrome.
Isr J Med Sci. 1996 Jan;32(1):29-31.

引用本文的文献

1
The Association of Class I and II Human Leukocyte Antigen Serotypes With End-Stage Kidney Disease Due to Membranoproliferative Glomerulonephritis and Dense Deposit Disease.I 类和 II 类人类白细胞抗原血清型与膜增生性肾小球肾炎和密性沉积物病导致的终末期肾病的相关性。
Am J Kidney Dis. 2024 Jan;83(1):79-89. doi: 10.1053/j.ajkd.2023.06.005. Epub 2023 Sep 20.
2
Pulmonary renal syndrome: a clinical review.肺肾综合征:临床综述
Breathe (Sheff). 2022 Dec;18(4):220208. doi: 10.1183/20734735.0208-2022. Epub 2023 Jan 10.
3
Glomerulonephritis in AKI: From Pathogenesis to Therapeutic Intervention.
急性肾损伤中的肾小球肾炎:从发病机制到治疗干预
Front Med (Lausanne). 2021 Mar 2;7:582272. doi: 10.3389/fmed.2020.582272. eCollection 2020.
4
Basement membranes and autoimmune diseases.基底膜与自身免疫性疾病。
Matrix Biol. 2017 Jan;57-58:149-168. doi: 10.1016/j.matbio.2016.07.008. Epub 2016 Aug 2.
5
Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy in first degree relatives: a case report.抗肾小球基底膜肾小球肾炎和血栓性微血管病一级亲属:病例报告。
BMC Nephrol. 2012 Jul 26;13:64. doi: 10.1186/1471-2369-13-64.
6
The relationship between genetics and environment in the pathogenesis of rheumatic diseases.遗传因素与环境因素在风湿性疾病发病机制中的关系。
West J Med. 1979 Sep;131(3):205-18.
7
Cellular aspects of vasculitis--T cell-mediated aspects.血管炎的细胞层面——T细胞介导的层面。
Springer Semin Immunopathol. 2001;23(3):287-98. doi: 10.1007/s002810100077.
8
Role of neutrophils in the pathogenesis of experimental vasculitis.中性粒细胞在实验性血管炎发病机制中的作用。
Am J Pathol. 1996 Jul;149(1):81-9.
9
Immunogenetics of glomerulonephritis.
Clin Investig. 1993 Oct;71(10):822-4. doi: 10.1007/BF00190329.
10
HLA antigens and scleroderma.人类白细胞抗原(HLA)抗原与硬皮病
Arch Dermatol Res. 1981;271(4):381-5. doi: 10.1007/BF00406682.