Koike S, Aoyama A, Yamaguchi N, Natori Y, Suzuki T, Itou M, Kusakabe K, Demura R
Radioassay Center, Tokyo Women's Medical College.
Rinsho Byori. 1993 Jun;41(6):666-72.
Serum concentrations of thyroid hormones (T3, T4, fT3 and fT4), TSH and TRAb in 14 mothers with Graves' disease at 1-4 weeks before delivery were comparably studied with cord blood hormone levels and various fetal states. Twelve mothers were on anti-thyroid drugs and 2 were drug-free, with 8 being euthyroid and 6 being hyperthyroid. Serum concentrations of T3, T4 and fT3 in cord blood were all the same regardless of maternal thyroidal function. Though cord blood TRAb levels correlated with maternal levels, cord fT4 levels were low in those who given antithyroid drugs. TSH levels in cord blood were low in Cesarean section delivery and babies with low birth weight. Birth weight and gestational weeks were both inversely correlated with maternal T4, fT4, fT3 and TRAb concentrations. Thus, maternal hormone levels at late stage of pregnancy in Graves' disease could be useful indices for perinatal risk.
对14例患有格雷夫斯病的母亲在分娩前1 - 4周的血清甲状腺激素（T3、T4、游离T3和游离T4）、促甲状腺激素（TSH）和促甲状腺素受体抗体（TRAb）水平与脐血激素水平及各种胎儿状态进行了比较研究。12名母亲正在服用抗甲状腺药物，2名未服药，其中8名甲状腺功能正常，6名甲状腺功能亢进。无论母亲的甲状腺功能如何，脐血中T3、T4和游离T3的血清浓度均相同。虽然脐血TRAb水平与母亲水平相关，但服用抗甲状腺药物的母亲所生婴儿的脐血游离T4水平较低。剖宫产分娩的婴儿和低出生体重儿的脐血TSH水平较低。出生体重和孕周均与母亲的T4、游离T4、游离T3和TRAb浓度呈负相关。因此，格雷夫斯病孕妇妊娠晚期的激素水平可能是围产期风险的有用指标。
