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Stringent factor from Escherichia coli directs ribosomal binding and release of uncharged tRNA.
Proc Natl Acad Sci U S A. 1976 Mar;73(3):707-11. doi: 10.1073/pnas.73.3.707.
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The stringent control mechanism. Binding of uncharged tRNA and stringent factor to Escherichia coli ribosomes.
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Dissection of the mechanism for the stringent factor RelA.
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Synthesis of guanosine tetra- and pentaphosphate requires the presence of a codon-specific, uncharged transfer ribonucleic acid in the acceptor site of ribosomes.
Proc Natl Acad Sci U S A. 1973 May;70(5):1564-8. doi: 10.1073/pnas.70.5.1564.
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Escherichia coli stringent factor binds to ribosomes at a site different from that of elongation factor Tu or G.
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Uncharged tRNA, protein synthesis, and the bacterial stringent response.
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Ribosome recycling factor and release factor 3 action promotes TnaC-peptidyl-tRNA Dropoff and relieves ribosome stalling during tryptophan induction of tna operon expression in Escherichia coli.
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Stringent factor binds to Escherichia coli ribosomes only in the presence of protein L10.
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70-S ribosomes of Escherichia coli have an additional site for deacylated tRNA binding.
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Codon-specific interaction of uncharged transfer-RNA with eukaryotic ribosomes.
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引用本文的文献
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Interaction studies on bacterial stringent response protein RelA with uncharged tRNA provide evidence for its prerequisite complex for ribosome binding.
Curr Genet. 2019 Oct;65(5):1173-1184. doi: 10.1007/s00294-019-00966-y. Epub 2019 Apr 9.
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Ribosome•RelA structures reveal the mechanism of stringent response activation.
Elife. 2016 Jul 19;5:e17029. doi: 10.7554/eLife.17029.
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The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.
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Recent functional insights into the role of (p)ppGpp in bacterial physiology.
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Near-critical behavior of aminoacyl-tRNA pools in E. coli at rate-limiting supply of amino acids.
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A cka-gfp transcriptional fusion reveals that the colicin K activity gene is induced in only 3 percent of the population.
J Bacteriol. 2003 Jan;185(2):654-9. doi: 10.1128/JB.185.2.654-659.2003.
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Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.
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Control of rRNA transcription in Escherichia coli.
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New aspects of the ribosomal elongation cycle.
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Testing an alternative model for the ribosomal peptide elongation cycle.
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Codon specific, tRNA dependent in vitro synthesis of ppGpp and pppGpp.
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Protein biosynthesis.
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A simple one-step method for the preparation of highly purified formylmethionine transfer ribonucleic acid and methionine transfer ribonucleic acid from Escherichia coli.
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A new transfer RNA fragment reaction: Tp psi pCpGp bound to a ribosome-messenger RNA complex induces the synthesis of guanosine tetra- and pentaphosphates.
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Synthesis of guanosine tetra- and pentaphosphate requires the presence of a codon-specific, uncharged transfer ribonucleic acid in the acceptor site of ribosomes.
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MSI and MSII made on ribosome in idling step of protein synthesis.
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Isolation and properties of a ribosome-bound factor required for ppGpp and ppGpp synthesis in Escherichia coli.
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Identification of the synthesis of guanosine tetraphosphate (MS I) as insertion of a pyrophosphoryl group into the 3'-position in guanosine 5'-diphosphate.
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