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多不饱和脂肪酸对小鼠皮肤同种异体移植存活及肿瘤发生率的影响。

Influence of polyunsaturated fatty acids on survival of skin allografts and tumor incidence in mice.

作者信息

Mertin J, Hunt R

出版信息

Proc Natl Acad Sci U S A. 1976 Mar;73(3):928-31. doi: 10.1073/pnas.73.3.928.

DOI:10.1073/pnas.73.3.928
PMID:768987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC336033/
Abstract

Subcutaneous or oral administration of the polyunsaturated fatty acid linoleic acid prolongs survival of skin allografts in mice. Mice fed on a diet deficient in polyunsaturated fatty acids show a relative immunopotentiation, as indicated by accelerated skin allograft rejection and decreased incidence and rate of development of methylcholanthrene-induced tumors. These observations support the hypothesis that polyunsaturated fatty acids take part in immunoregulatory mechanisms.

摘要

皮下或口服多不饱和脂肪酸亚油酸可延长小鼠皮肤同种异体移植的存活时间。以缺乏多不饱和脂肪酸的饮食喂养的小鼠表现出相对的免疫增强，这可通过皮肤同种异体移植排斥加速以及甲基胆蒽诱导肿瘤的发生率和发展速度降低来表明。这些观察结果支持了多不饱和脂肪酸参与免疫调节机制的假说。

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Influence of polyunsaturated fatty acids on survival of skin allografts and tumor incidence in mice.多不饱和脂肪酸对小鼠皮肤同种异体移植存活及肿瘤发生率的影响。
Proc Natl Acad Sci U S A. 1976 Mar;73(3):928-31. doi: 10.1073/pnas.73.3.928.
2
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本文引用的文献

1
Absence of enhancing antibody in cell mediated immunity to tumour heterografts in protein deficient rats.蛋白质缺乏大鼠对肿瘤异种移植物的细胞介导免疫中增强抗体的缺失。
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Letter: Prolongation of skin allografts in rats by treatment with linoleic acid.信函：用亚油酸处理延长大鼠同种异体皮肤移植存活时间
Lancet. 1974 Nov 30;2(7892):1331. doi: 10.1016/s0140-6736(74)90203-7.
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The effects of a series of prostaglandins on in vitro models of the allergic response and cellular immunity.
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Immune resistance and malnutrition.免疫抵抗与营养不良。
Lancet. 1972 Feb 5;1(7745):314. doi: 10.1016/s0140-6736(72)90309-1.
8
Specific inhibitory action of polyunsaturated fatty acids on lymphocyte transformation induced by PHA and PPD.多不饱和脂肪酸对PHA和PPD诱导的淋巴细胞转化的特异性抑制作用。
Int Arch Allergy Appl Immunol. 1975;48(2):203-10. doi: 10.1159/000231306.