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1
Anti-cancer action of retinoids.维甲酸的抗癌作用。
Immunology. 1981 Feb;42(2):349-53.
2
Orchidectomy and immune response.睾丸切除术与免疫反应。
Ann R Coll Surg Engl. 1976 Sep;58(5):359-67.
3
Bromocriptine prevents the immunosuppression induced in mice by anti-lymphocytic antiserum.溴隐亭可预防抗淋巴细胞抗血清诱导的小鼠免疫抑制。
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Effect of 6-mercaptopurine-rabbit-anti-mouse lymphocyte globulin on the survival of skin allografts in mice.6-巯基嘌呤-兔抗小鼠淋巴细胞球蛋白对小鼠同种异体皮肤移植存活的影响。
Folia Biol (Praha). 1982;28(1):22-7.
5
Extended skin allo- and xenograft survival in mice treated with rapamycin, antilymphocyte serum, and donor-specific bone marrow transfusion.用雷帕霉素、抗淋巴细胞血清和供体特异性骨髓输注治疗的小鼠中皮肤同种异体和异种移植物存活期延长
Transplant Proc. 1996 Dec;28(6):3269.
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Histologic studies of lymphoid tissues in mice treated with immunosuppressive agents to prolong skin allografts.
Nihon Geka Hokan. 1968 Sep 1;37(5):608-22.
7
Asialo GM1 positive CD8+ T cells induce skin allograft rejection in the absence of the secondary lymphoid organs.去唾液酸GM1阳性CD8 + T细胞在无次级淋巴器官的情况下诱导皮肤同种异体移植排斥反应。
J Surg Res. 2005 Nov;129(1):57-63. doi: 10.1016/j.jss.2005.07.009. Epub 2005 Sep 2.
8
Synergistic effect of immunosuppressive drug and intrathymic inoculation of donor cells in skin graft survival.免疫抑制药物与胸腺内接种供体细胞对皮肤移植存活的协同作用。
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Enhancement by retinyl acetate of hormone-induced mammary tumorigenesis in female GR/A mice.
J Natl Cancer Inst. 1981 Oct;67(4):935-8.

引用本文的文献

1
Increased leucoattractant binding and reversible inhibition of neutrophil motility mediated by the peroxidase/H2O2/halide system: effects of ascorbate, cysteine, dithiothreitol, levamisole and thiamine.过氧化物酶/H2O2/卤化物系统介导的白细胞趋化因子结合增加及中性粒细胞运动的可逆抑制：抗坏血酸、半胱氨酸、二硫苏糖醇、左旋咪唑和硫胺素的作用。
Clin Exp Immunol. 1982 Feb;47(2):487-96.
2
Enhancement of specific antitumor immunity in mice fed a diet enriched in vitamin A acetate.给喂食富含醋酸维生素A饮食的小鼠增强特异性抗肿瘤免疫力。
Proc Natl Acad Sci U S A. 1983 Oct;80(20):6322-6. doi: 10.1073/pnas.80.20.6322.
3
Clinical implications of current studies in carcinogenesis.当前致癌作用研究的临床意义。
J Cancer Res Clin Oncol. 1984;108(3):264-73. doi: 10.1007/BF00390456.
4
Supplemental vitamin A prevents the acute radiation-induced defect in wound healing.补充维生素A可预防急性辐射引起的伤口愈合缺陷。
Ann Surg. 1984 Oct;200(4):494-512. doi: 10.1097/00000658-198410000-00011.
5
Inhibition of growth and metastasis of syngeneic transplantable tumours by an aromatic retinoic acid analogue. 2. T cell dependence of retinoid effects in vivo.一种芳香维甲酸类似物对同基因可移植肿瘤生长和转移的抑制作用。2. 维甲酸体内效应的T细胞依赖性。
Cancer Immunol Immunother. 1985;19(2):115-20. doi: 10.1007/BF00199718.
6
Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin 2 or vitamin A acetate.重组白细胞介素2或醋酸维生素A会损害对外源细胞的获得性免疫耐受性。
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7
Regulation of accessory cell function by retinoids in murine immune responses.视黄酸对小鼠免疫反应中辅助细胞功能的调节作用。
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本文引用的文献

1
An inhibitory effect of vitamin A on the induction of tumors of forestomach and cervix in the Syrian hamster by carcinogenic polycyclic hydrocarbons.维生素A对叙利亚仓鼠中由致癌多环烃诱导的前胃和子宫肿瘤的抑制作用。
Cancer Res. 1965 Jul;25(6):884-95.
2
Nature and mode of action of antilymphocytic antiserum.抗淋巴细胞抗血清的性质与作用方式。
Proc Natl Acad Sci U S A. 1966 Oct;56(4):1130-7. doi: 10.1073/pnas.56.4.1130.
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Vitamin A compounds and analogs as inhibitors of mixed-function oxidases that metabolize carcinogenic polycyclic hydrocarbons and other compounds.
Cancer Res. 1974 Mar;34(3):564-70.
4
Prophylaxis of chemically induced benign and malignant epithelial tumors by vitamin A acid (retinoic acid).维生素A酸（视黄酸）对化学诱导的良性和恶性上皮肿瘤的预防作用
Eur J Cancer (1965). 1972 Dec;8(6):689-93. doi: 10.1016/0014-2964(72)90153-3.
5
Accelerated rejection of skin homografts by vitamin A acid.维甲酸加速皮肤同种异体移植的排斥反应。
Transplantation. 1972 Nov;14(5):564-7. doi: 10.1097/00007890-197211000-00006.
6
Adjuvanticity of vitamin A.维生素A的佐剂性
Nature. 1968 Feb 10;217(5128):527-9. doi: 10.1038/217527a0.
7
Dietary vitamin A and human lung cancer.
Int J Cancer. 1975 Apr 15;15(4):561-5. doi: 10.1002/ijc.2910150405.
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13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat.
Science. 1977 Feb 4;195(4277):487-9. doi: 10.1126/science.835006.
9
Inhibition of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis by retinyl acetate.醋酸视黄酯对7,12-二甲基苯并(a)蒽诱导的乳腺癌发生的抑制作用。
Cancer Res. 1976 Jul;36(7 PT 2):2626-30.
10
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design.需要对每位患者进行长期观察的随机临床试验的设计与分析。I. 引言与设计。
Br J Cancer. 1976 Dec;34(6):585-612. doi: 10.1038/bjc.1976.220.

维甲酸的抗癌作用。

Anti-cancer action of retinoids.

作者信息

Medawar P B, Hunt R

出版信息

Immunology. 1981 Feb;42(2):349-53.

PMID:7007222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458075/
Abstract

The anti-cancer action of retinyl acetate (Vitamin-A acetate, VAA), chosen as a representative retinoid substance, is attributed to its power to exercise immunopotentiation, though other possibilities are considered. The reasons for forming this opinion were: (1) chronic administration of VAA brought about enlargement of the thymus and peripheral lymph nodes; (2) the administration of VAA curtailed the life of skin allografts though (3) its action could be reversed by the concomitant administration of immunosuppressive agents.

摘要

作为代表性类视黄醇物质的醋酸视黄酯（维生素A醋酸酯，VAA）的抗癌作用，尽管还考虑了其他可能性，但归因于其具有免疫增强能力。形成这一观点的原因如下：（1）长期给予VAA会导致胸腺和外周淋巴结肿大；（2）给予VAA会缩短皮肤同种异体移植的存活时间，不过（3）其作用可通过同时给予免疫抑制剂而逆转。