维甲酸的抗癌作用。
Anti-cancer action of retinoids.
作者信息
Medawar P B, Hunt R
出版信息
Immunology. 1981 Feb;42(2):349-53.
Abstract
The anti-cancer action of retinyl acetate (Vitamin-A acetate, VAA), chosen as a representative retinoid substance, is attributed to its power to exercise immunopotentiation, though other possibilities are considered. The reasons for forming this opinion were: (1) chronic administration of VAA brought about enlargement of the thymus and peripheral lymph nodes; (2) the administration of VAA curtailed the life of skin allografts though (3) its action could be reversed by the concomitant administration of immunosuppressive agents.
摘要
作为代表性类视黄醇物质的醋酸视黄酯（维生素A醋酸酯，VAA）的抗癌作用，尽管还考虑了其他可能性，但归因于其具有免疫增强能力。形成这一观点的原因如下：（1）长期给予VAA会导致胸腺和外周淋巴结肿大；（2）给予VAA会缩短皮肤同种异体移植的存活时间，不过（3）其作用可通过同时给予免疫抑制剂而逆转。
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