Jordon R E, McDuffie F C
Proc Soc Exp Biol Med. 1976 Mar;151(3):594-8. doi: 10.3181/00379727-151-39267.
By sucrose density gradient ultracentrifugation and standard hemolytic complement assays, complement fixing activity of about 19 S and greater was found in blister fluids of one patient with pemphigus and three of five patients with bullous pemphigoid. Control blister fluids, including experimentally induced blisters, lacked such activity. Complement fixing activity was apparent, however, in 6 of 10 pemphigus sera and in two of five bullous pemphigoid sera tested. The material present in both pemphigus and bullous pemphigoid appears to activate the classical complement pathway.
通过蔗糖密度梯度超速离心和标准溶血补体测定法，在1例天疱疮患者的水疱液以及5例大疱性类天疱疮患者中的3例水疱液中发现了约19 S及更大的补体固定活性。对照水疱液，包括实验诱导的水疱，均缺乏这种活性。然而，在检测的10份天疱疮血清中的6份以及5份大疱性类天疱疮血清中的2份中，补体固定活性明显。天疱疮和大疱性类天疱疮中存在的物质似乎激活了经典补体途径。
