Miyaguchi M, Takeda J, Furuta H, Uozumi N, Miyabe K, Sakai S
Department of Otolaryngology, Kagawa Medical School.
Nihon Jibiinkoka Gakkai Kaiho. 1993 Jul;96(7):1099-104. doi: 10.3950/jibiinkoka.96.1099.
The effects of granulocyte colony stimulating factor (G-CSF) were evaluated in 9 patients with malignant lymphoma of the head and neck. The effects of 31 cycles of cytotoxic chemotherapy were treated with G-CSF. G-CSF was given by one of the following three routes: 1) administration before or with cytotoxic chemotherapy, 2) administration after cytotoxic chemotherapy with leukocyte counts of more than 2000/mm3, and 3) administration after leukocyte counts had dropped to less than 2000/mm3. The first group consisted of one cycle of CHOP therapy and 2 cycles of VAMA therapy. The second group consisted of 10 cycles of CHOP therapy. The third group consisted of 13 cycles of CHOP therapy and 5 cycles of VAMA therapy. Leukocyte nadirs occurred on around day 14 for CHOP therapy and around day 21 for VAMA therapy without G-CSF treatment. In the first group, the leukocyte nadirs occurred earlier with G-CSF treatment. Additional G-CSF treatments were given in two of the three cycles. In the second group, the leukocyte counts did not drop below 2000/mm3 in three of the ten cycles. Additional G-CSF treatments were given in five of the remaining seven cycles. The two other cycles went without additional treatment. The mean volume of G-CSF was 305 +/- 86 micrograms. In the third group, the leukocyte counts increased to more than 2000/mm3 immediately after G-CSF administration in CHOP therapy. The mean volume was 227 +/- 78 micrograms, significantly less than that of the second group. The leukocyte counts also exceeded 2000/mm3 3-5 days after G-CSF administration in 5 cycles of VAMA therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
对9例头颈部恶性淋巴瘤患者评估了粒细胞集落刺激因子（G-CSF）的效果。31个周期的细胞毒性化疗采用G-CSF治疗。G-CSF通过以下三种途径之一给药：1）在细胞毒性化疗之前或同时给药；2）在细胞毒性化疗后白细胞计数超过2000/mm³时给药；3）在白细胞计数降至低于2000/mm³后给药。第一组包括1个周期的CHOP疗法和2个周期的VAMA疗法。第二组包括10个周期的CHOP疗法。第三组包括13个周期的CHOP疗法和5个周期的VAMA疗法。在未使用G-CSF治疗的情况下，CHOP疗法的白细胞最低点出现在第14天左右，VAMA疗法的白细胞最低点出现在第21天左右。在第一组中，使用G-CSF治疗时白细胞最低点出现得更早。三个周期中有两个周期给予了额外的G-CSF治疗。在第二组中，十个周期中有三个周期白细胞计数未降至低于2000/mm³。其余七个周期中有五个周期给予了额外的G-CSF治疗。另外两个周期未进行额外治疗。G-CSF的平均用量为305±86微克。在第三组中，CHOP疗法中G-CSF给药后白细胞计数立即升至超过2000/mm³。平均用量为227±78微克，明显低于第二组。在5个周期的VAMA疗法中，G-CSF给药后3 - 5天白细胞计数也超过了2000/mm³。（摘要截短至250字）
