Gene structure and expression in colorectal cancer.
作者信息
Pipas J M, Pogue-Geile K, Finley G G, Cartwright C A, Meiesler A I
机构信息
Department of Biological Sciences, University of Pittsburgh, PA 15260.
出版信息
Adv Exp Med Biol. 1993;330:67-75. doi: 10.1007/978-1-4615-2926-2_6.
PMID:7690179
Abstract
Colorectal cancer provides a unique model for the study of molecular changes that are associated with tumorigenesis. The cancer evolves as an apparent ordered sequence from a benign to a malignant lesion in histopathological recognizable stages. Since it is relatively easy to isolate tissue representing each of these stages, studies of molecular events associated with tumor progression are feasible. Such studies have shown that multiple changes in gene structure, expression and activity occur during tumorigenesis.
摘要
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