Relation of blood pressure circadian rhythm to cardiovascular complaints and orthostatic test results in patients with orthostatic dysregulation. Effects of midodrine on blood pressure circadian rhythm.

Twenty patients with orthostatic dysregulation were studied in order to clarify the relation of blood pressure (BP) circadian rhythm to cardiovascular complaints and orthostatic test results. There was a significant negative correlation between the number of cardiovascular complaints and 24 hour (hr) maximum (Mx) and day-time Mx BPd. A significant negative correlation was also obtained between the decrease in TII amplitude in upright posture and nighttime standard deviation and range of BPs and BPd. Decrease of BPs in upright posture was significantly correlated with 24 hr and nighttime minimum (Mn) BPd. The above results indicate that cardiovascular complaints and orthostatic test results are related with BPd, as well as BPs.