Riddell D A, Lampe H B, Cramer H, Troster M
Department of Otolaryngology, University of Western Ontario, London, Canada.
J Otolaryngol. 1993 Jun;22(3):180-3.
Medullary thyroid carcinoma is an uncommon cancer of the thyroid gland. It comprises a neuroendocrine tumor of the calcitonin secreting cells. Its level of aggressiveness lies between that of well-differentiated and anaplastic thyroid malignancies. We have undertaken a retrospective study of 18 patients with medullary thyroid carcinoma to evaluate various parameters for their prognostic value. We looked at epidemiologic factors such as stage, age at onset, sex and the heredity of the disease. In addition various immunohistochemical stains were looked at including Leu-M1, calcitonin, thyroglobulin, somatostatin, carcinoembryonic antigen, neuron specific enolase and BRST-1. Finally, DNA ploidy was determined using the flow cytometer. Stage, age at onset, DNA ploidy and staining for BRST-1 were found to be significant factors in determining outcome of this disease.
甲状腺髓样癌是一种不常见的甲状腺癌。它是由分泌降钙素的细胞构成的神经内分泌肿瘤。其侵袭性介于高分化和未分化甲状腺恶性肿瘤之间。我们对18例甲状腺髓样癌患者进行了一项回顾性研究，以评估各种参数的预后价值。我们研究了诸如分期、发病年龄、性别和疾病遗传等流行病学因素。此外，还观察了各种免疫组化染色，包括Leu-M1、降钙素、甲状腺球蛋白、生长抑素、癌胚抗原、神经元特异性烯醇化酶和BRST-1。最后，使用流式细胞仪测定DNA倍性。分期、发病年龄、DNA倍性和BRST-1染色被发现是决定该疾病预后的重要因素。
