Böttger T, Potratz D, Gabbert H, Schernus B, Stöckle M, Klupp J, Junginger T
Klinik und Poliklinik für Allgemein- und Abdominalchirurgie, Johannes-Gutenberg-Universität Mainz.
Chirurg. 1993 Feb;64(2):122-9.
In 24 patients with a medullary thyroid cancer a histopathological reexamination was performed. In 16 patients the DNA content was measured. Patients with a diploid or hypotriploid tumor had a 5-year survival rate of 100% in contrast to 48% of patients with a triploid or hypertriploid aneuploid tumor. Aneuploid tumors were more often found in patients with a high pre- or postoperative calcitonin level and lymph node metastasis. No correlation was found between the DNA content and the patients age, sex, preoperative CEA value, tumor size, pT4 stage, invasion of vessels calcitonin immunoreactivity, silver or amyloid staining, and distant metastasis.
对24例甲状腺髓样癌患者进行了组织病理学复查。对其中16例患者测量了DNA含量。二倍体或亚三倍体肿瘤患者的5年生存率为100%，而三倍体或超三倍体非整倍体肿瘤患者的5年生存率为48%。非整倍体肿瘤更常见于术前或术后降钙素水平高且有淋巴结转移的患者。未发现DNA含量与患者年龄、性别、术前癌胚抗原值、肿瘤大小、pT4分期、血管侵犯、降钙素免疫反应性、银染或淀粉样染色以及远处转移之间存在相关性。
