Susek R E, Ausubel F M, Chory J
Plant Biology Laboratory, Salk Institute for Biological Studies, San Diego, California 92186-5800.
Cell. 1993 Sep 10;74(5):787-99. doi: 10.1016/0092-8674(93)90459-4.
Chloroplast development requires coordinate nuclear and chloroplast gene expression. A putative signal from the chloroplast couples the transcription of certain nuclear genes encoding photosynthesis-related proteins with chloroplast function. We have identified at least three Arabidopsis nuclear genes (GUN1, GUN2, and GUN3) necessary for coupling the expression of some nuclear genes to the functional state of the chloroplast. Homozygous recessive gun mutations allow nuclear gene expression in the absence of chloroplast development and furthermore may interfere with the switch from dark-grown to light-grown development. Other reports suggest this intracellular cross-talk also involves mitochondrial interactions. The GUN genes thus define steps in one specific branch of a complex interorganellar regulatory network.
叶绿体的发育需要细胞核与叶绿体基因表达的协同作用。来自叶绿体的一种假定信号将某些编码光合作用相关蛋白的核基因的转录与叶绿体功能联系起来。我们已经鉴定出至少三个拟南芥核基因（GUN1、GUN2和GUN3），它们是将一些核基因的表达与叶绿体功能状态相联系所必需的。纯合隐性枪突变允许在没有叶绿体发育的情况下进行核基因表达，并且还可能干扰从暗生长到光生长发育的转变。其他报告表明，这种细胞内的相互作用还涉及线粒体的相互作用。因此，GUN基因定义了复杂的细胞器间调节网络一个特定分支中的步骤。
