Gershoni J M, Denisova G, Raviv D, Smorodinsky N I, Buyaner D
Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.
FASEB J. 1993 Sep;7(12):1185-7. doi: 10.1096/fasebj.7.12.7690724.
Effective vaccines against the human immunodeficiency virus (HIV) must cope with the genetic variation of the viral envelope (gp120) to combat or prevent acquired immunodeficiency syndrome (AIDS). Here we describe novel epitopes that are accentuated when gp120 complexes with its receptor (CD4). The presentation of these epitopes results through conformational rearrangements in the CD4/gp120 complex. Monoclonal antibodies directed to these epitopes inhibit syncytium formation, thus indicating the potential use of these epitopes as subunit vaccines.
有效的抗人类免疫缺陷病毒（HIV）疫苗必须应对病毒包膜（gp120）的基因变异，以对抗或预防获得性免疫缺陷综合征（AIDS）。在此，我们描述了新的表位，当gp120与其受体（CD4）结合时，这些表位会被增强。这些表位的呈现是通过CD4/gp120复合物中的构象重排实现的。针对这些表位的单克隆抗体可抑制合胞体形成，因此表明这些表位作为亚单位疫苗具有潜在用途。
