从白斑到干细胞：Kit受体在哺乳动物发育中的作用
From white spots to stem cells: the role of the Kit receptor in mammalian development.
作者信息
Fleischman R A
机构信息
Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75235-8852.
出版信息
Trends Genet. 1993 Aug;9(8):285-90. doi: 10.1016/0168-9525(93)90015-a.
PMID:7691001
Abstract
The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.
摘要
Kit酪氨酸激酶膜受体在胚胎发育和出生后的生命过程中对黑素生成、配子发生和造血作用至关重要。本综述总结了涉及Kit及其配体Steel因子在干细胞增殖、迁移和存活控制方面的遗传学证据，重点关注人类和小鼠基因中的突变。
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