Hanash S M, Beretta L, Barcroft C L, Sheldon S, Glover T W, Ungar D, Sonenberg N
Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor.
Genes Chromosomes Cancer. 1993 Sep;8(1):34-7. doi: 10.1002/gcc.2870080107.
Recent evidence suggests that the human interferon-inducible double-stranded RNA-dependent protein kinase may function as a tumor suppressor. Here we describe the mapping of the gene for this kinase to chromosome region 2p21-22 by fluorescence in situ hybridization. A combined analysis of cytogenetic data from a series of 341 patients with hematologic disorders that exhibited cytogenetic abnormalities and from published reports indicates that abnormalities involving 2p21-22 occur nonrandomly and are observed among patients with acute myelogenous leukemia, raising the possibility of a role for this protein kinase in leukemogenesis.
最近的证据表明，人类干扰素诱导的双链RNA依赖性蛋白激酶可能具有肿瘤抑制功能。在此，我们通过荧光原位杂交描述了该激酶基因定位于染色体区域2p21-22。对一系列341例患有细胞遗传学异常的血液系统疾病患者的细胞遗传学数据与已发表报告进行的综合分析表明，涉及2p21-22的异常并非随机发生，在急性髓性白血病患者中可观察到，这增加了该蛋白激酶在白血病发生中发挥作用的可能性。
