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Localization of the human interferon-induced, ds-RNA activated p68 kinase gene (PRKR) to chromosome 2p21-p22.

作者信息

Squire J, Meurs E F, Chong K L, McMillan N A, Hovanessian A G, Williams B R

机构信息

Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.

出版信息

Genomics. 1993 Jun;16(3):768-70. doi: 10.1006/geno.1993.1263.

DOI:10.1006/geno.1993.1263
PMID:7686884
Abstract

The interferon-induced dsRNA-activated protein kinase (PRKR) belongs to a subclass of serine/threonine kinases, involved in the regulation of protein synthesis by phosphorylation of the alpha subunit of initiation factor eIF2. Somatic cell hybrids segregating human chromosomes were used to assign this kinase to human chromosome 2. Fluorescence in situ hybridization confirmed this assignment and further localized the gene (PRKR) to the boundary region of bands p21 and 22.

摘要

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